AAP 2022 Hyperbilirubinemia Management Guidelines

Calculator and clinical decision support for the AAP 2022 guidelines for the management of hyperbilirubinemia in newborns 35 or more weeks of gestation.



GA at birth40 completed weeks
Postnatal age48 hours
Bilirubin10 mg/dL
Phototherapy thresholdExchange threshold
No neurotoxicity risk factors
17 mg/dL24 mg/dL
ANY neurotoxicity risk factors
14 mg/dL20.1 mg/dL



Thresholds for Phototherapy, Escalation of Care, and Exchange Transfusion


Difference between phototherapy threshold and last bilirubin measurement


Post-birth hospitalization discharge follow-up for infants who have NOT received phototherapy

Phototherapy threshold minus bilirubin measurementDischarge recommendations
0.1 - 1.9 mg/dLAge <24 hoursDelay discharge, consider phototherapy, measure TSB in 4 to 8 hours
Age ≥24 hoursMeasure TSB in 4 to 24 hours. Options:
  • Delay discharge and consider phototherapy
  • Discharge with home phototherapy if all considerations in the guideline are met
  • Discharge without phototherapy but with close follow-up
2.0 - 3.4 mg/dL(regardless of age)TSB or TcB in 4 to 24 hours
3.5 - 5.4 mg/dL(regardless of age)TSB or TcB in 1– 2 days
5.5 - 6.9 mg/dLDischarging <72 hoursFollow-up within 2 days; TcB or TSB according to clinical judgment
Discharging ≥72 hoursClinical judgment
≥7.0 mg/dLDischarging <72 hoursFollow-up within 3 days; TcB or TSB according to clinical judgment
Discharging ≥72 hoursClinical judgment

(Complete discharge follow-up table may be helpful to provide comparative context)



Age and Bilirubin

Gestation at birth
Age (hours)
Bilirubin (mg/dL)
Neurotoxicity risks
(required)
No risk factors
ANY risk factors
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Optional age calculator
Date of birth
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Script by Joseph Chou, 2023-08-15

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The User acknowledges and agrees that this tool will be used only as a reference aid, and that the information contained in the product is not intended to be (nor should it be used as) a substitute for the exercise of professional judgement.

In view of the possibility of human error or changes in medical science, the User should confirm the information in the product through independent sources. This product is provided without warranties of any kind, express or implied, and the author disclaims any liability, loss, or damage caused by it or its content.

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Neurotoxicity Risk Factors

Based on